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Serum and Fecal Biomarker Targets CRP and fecal calprotectin Fecal calprotectin demonstrates the highest sensitivity (82%), specificity (72%), PPV, NPV Fecal calprotectin has a higher correlation with disease activity in the colon vs the ileum Threshold target: most prognostic significance Cutoff of 150 ug/g = gray zone <600 ug/g = possible ...
Aug 3, 2022 · We evaluated the value of post-induction fecal calprotectin (FCP) concentration as a biomarker in patients with ulcerative colitis (UC) treated with a biologic.
Jul 18, 2024 · The development of noninvasive markers to assess mucosal healing in ulcerative colitis (UC) is essential in the treat-to-target era. The aim of this study was to evaluate the performance of intestinal ultrasound (IUS), fecal calprotectin (FC), and their combination to assess mucosal healing in UC patients.
Jan 30, 2023 · In 2021, the Selection of Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative proposed updated recommendations for treatment targets for ulcerative colitis (UC) patients. The recommendations introduce clinical remission as a short/medium term target, normalisation of CRP and Fecal Calprotectin (FC) as an intermediate target, and advice that …
STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology. 2021;160 (5):1570-1583.
Median time to event was longer than STRIDE-II recommendations for all monitoring outcomes. Conclusion: Median time to disease monitoring activities increased between 2008-2021 despite the publication of the STRIDE guidelines. More intensive monitoring is needed to achieve “treat-to-target” guidelines.
In the treat-to-target strategy, fecal calprotectin is considered an adjunctive biomarker, rather than a treatment target, in measuring treatment response and mucosal healing and predicting relapse.
Jun 20, 2025 · Purpose of review The treatment of inflammatory bowel disease (IBD) has evolved significantly over time based on “treat-to-target”, an approach which uses sequential objective makers to monitor response to therapy with the ultimate goal of achieving endoscopic healing. Biomarkers, including C-reactive protein and fecal calprotectin, are an important noninvasive …
Jun 9, 2020 · The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) group, has updated the 2015 STRIDE recommendations and has developed 13 updated and new recommendations for treating to target in Crohn's disease and ulcerative colitis, in …
Although the primary goal of therapy in UC has traditionally been to control symptoms of bleeding and diarrhea, the recently published Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE; Am J Gastroenterol 2015;110:873–880) guidelines have advocated inclusion of an objective measure of response, namely endoscopy, as a ...
Elevated fecal calprotectin should prompt endoscopic assessment, whether or not the patient is symptomatic. Conclusion The treat-to-target approach to therapy has the potential to change patient outcomes. Prospective studies are, however, still needed to determine how effectively this approach changes disease course and patients’ quality of life.
Feb 1, 2023 · The value of post-induction fecal calprotectin (FCP) concentration as a predictor of long-term outcomes relative to other early response measures was evaluated in patients with ulcerative colitis (UC) treated with a biologic.
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